Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma

Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma

Blog Article

We report a new lycogel 131I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma.In this study, polyethyleneimine (PEI) based nanogels (P.NH2 NGs) were prepared by water/oil polymerization, modified with targeted agent phenylboronic acid (PBA), and labeled with radionuclide 131I.The NGs without 131I-labeling own a spherical structure, uniform size distribution, and good cell viability.After 131I-labeling, the obtained 131I-PBA-PHP NGs displayed much higher cellular uptake than the non-targeted NGs due to the good softness and fluidity of NGs and the PBA targeting.

The in vivo results demonstrated that 131I-PBA-PHP NGs could specifically target breast cancer cells click here and efficiently aggregate into xenograft breast adenocarcinoma for tumor SPECT imaging and specific radiotherapy.The developed 131I-labeling NGs may be used as a promising platform for efficient radioactive theranostic nanoplatform of tumor.